Some of Second Presbyterian Church's national mission projects include:

Yupik Outreach
In partnership with Chukotka Native Christian Ministries, Presbyterians and the Presbytery of Yukon reach out to native Yupiks of the Russian Far East. A particular focus is on teaching evangelism and training Yupik leadership so that churches can multiply in Siberia.
Second Presbyterian Church contributes $6,000 which assists the Yukon Presbytery, in ecumenical partnership with four other denominations, in preparing and sending Yupik (Eskimo) evangelists to the native peoples of Siberia. New believers from Siberia after rigorous training are encouragement to serve as house church leaders and Bible study leaders in their home villages. The goal is to establish an indigenous, self-sustaining church among the native peoples of the Chukotka Peninsula of Siberia. For more information click on link.

Witnessing Ministries of Christ
Witnessing Ministries of Christ spreads the Good News among the 135 million Dalit (or Untouchable) people of India. Second Presbyterian Church contributes $7000 a year to this ministry. A mass evangelism movement is underway among the Bhangi people in Uttar Pradesh. An average of 10,500 people come to Jesus Christ a month. In order to welcome these new Christians and nurture them in the faith 260 pastor-couples have to be trained each year. The Rural Presbyterian Church requires that both husband and wife commit to work as pastors together. This insures that women receive full pastoral care, which a male alone is not able to do under the rules of the culture. Over the last 10 years 1,329 pastor-couples have been trained who are serving 16,171 village congregations. Each couple serves 12 villages within a radius of five or ten miles The Witnessing Ministries of Christ promotes six ministry branches of evangelism, pastoral care, education, health, economic development and reconciliation.

Baale Suri Project Ethiopia (PCUSA missionaries John and Gwen Haspels)
Second Presbyterian Church contributes $7000 a year to the Baale Suri Project the goal of this mission is to establish a first generation church in the southern region of Ethiopia. There are approximately 3500-4000 people in the region. The people in this area cultivate small gardens and depend on honey gathering and panning for gold as their primary income generating occupations. There are no roads into the area. The people have no access to health facilities or schools. Potable water is a significant problem with many having to collect water from 3-5km away.

In 2000, three Baale chiefs came to the Surma Project headquarters in Tulegit and spoke with the project coordinator. They said, “We see that the Suri people here have the light. We Baale are still in the darkness. We want the light. Please come and bring us light.” The priorities of this mission project as presented by the village elders are first to provide health care services. The second priority of these elders is water and thirdly education. The forth priority is construction of a road for health and trade reasons.